Heart Rhythm Congress 2011

Abstracts

All abstracts selected for HRC 2011 will be published in Europace, Volume 13, Supplement 4 - this will be available online from Friday 30th September.

Young Investigators Competition

The winners are:

Clinical

Novel Restitution Gradient Based Predictor of Ventricular Arrhythmia
WB Nicolson, P Brown, J Tuan, AJ Sandilands, PJ Stafford, FS Schlindwein, GP McCann, GA Ng (Leicester Cardiovascular Biomedical Research Unit, UK; University Hospitals of Leicester NHS Trust, UK; University of Leicester, UK)

Basic Science

The Funny Current can be used to Create a Biological Pacemaker by Enhancement of the Pacing Rate of Subsidiary Pacemaker Tissue in a Model of Sick Sinus Syndrome, but the Effectiveness of Different HCN Isoforms Markedly Differs
GM Morris, H Dobrzynki, M Lei, Y Kryukova, RB Robinson, PA Kingston, MR Boyett (University of Manchester, UK; Columbia University, New York USA)

Runners up:

Characterisation of Fractionated Atrial Electrograms Critical for Maintenance of AF: A Randomised Controlled Trial of Ablation Strategies (The CFAE AF trial)
RJ Hunter, I Diab, M Tayebjee, L Richmond, S Sporton, MJ Earley, RJ Schilling (Barts and the London NHS Trust & Queen Mary University of London, UK)

Multipolar Left Ventricular Pacing to Optimise Acute Haemodynamic Response to Cardiac Resynchronisation Therapy
SY Ahsan, C Koo, AB Gopalamurugan, P Lambiase, GG Babu, S Aggarwal, A Suri, OR Segal, MD Lowe, L Nunn, E Rowland, AWC Chow (The Heart Hospital, London UK)

Electrophysiological Abnormalities Precede Overt Structural Changes in Arrhythmogenic Right Ventricular Cardiomyopathy due to Mutations in Desmoplakin
JC Gomes, M Finlay, AK Ahmed, EJ Ciaccio, A Pantazis, A Asimaki, J Saffitz, M Nobles, P Syrris, G Quarta, L Xul, S Chaubey, RB Simon, AW Chow, O Segal, MD Lowe, WJ McKenna, A Tinker, PD Lambiase (University College London, UK; The Heart Hospital, London UK; Columbia University, New York USA; Beth Israel Deaconess Medical Centre, Boston USA; Kings College London, UK)

Cardiac Contractility Modulation (CCM) decreases the Ventricular Fibrillation threshold in the Isolated Rabbit Heart through a Beta1-Adrenoceptor Dependent Mechanism
J Winter, K Brack, GA Ng (University of Leicester, UK)

Oral Abstracts 1

Atrial Fibrillation

7. The Use of Oral Anti-Coagulants in the Management of Atrial Fibrillation. National Data from GRASP-AF
R Healicon, J Barrett, M Fay, A Graham, K Griffith, K Tyndall, C Cowan (NHS Improvement, Leicester UK; University of Nottingham, UK; NHS Improvement, Bradford UK; West Yorkshire Cardiac and Stroke Network, Bradford UK; West Yorkshire Cardiac and Stroke Network, York UK; Leeds General Infirmary, UK; NHS Improvement, Leeds UK)

8. The Increasing Burden of Atrial Fibrillation on Healthcare in Scotland
AM Choy, C Righetti, M Keech (Ninewells Hospital and Medical School, Newcastle UK; Sanofi-Aventis, Guildford UK; Pharmakos Ltd, St Albans UK)

9. A Randomised Controlled Trial of Catheter Ablation versus Medical Treatment of Atrial Fibrillation in Heart Failure (The CAMTAF trial)
RJ Hunter, TJ Berriman, I Diab, R Kamdar, L Richmond, V Baker, F Goromonzi, E Duncan, V Sawhney, B Unsworth, J Mayet, D Abrams, M Dhinoja, MJ Earley, S Sporton, RJ Schilling (Barts and the London NHS Trust & Queen Mary University of London, UK; International Centre for Circulatory Health, St Mary's Hospital, Imperial College London, UK

10. A Randomised Trial of Cryoablation vs. Radiofrequency Ablation vs. both for Paroxysmal AF
ER Duncan, RJ Hunter, M Tayebjee, V Baker, MS Siddiqui, F Goromonzi, L Richmond, M Dhinoja, S Sporton, MJ Earley, RJ Schilling (Barts and the London NHS Trust & Queen Mary University of London, UK)

11. Does Catheter Ablation of Atrial Fibrillation reduce Risk of Stroke and Death?
RJ Hunter, J McCready, I Diab, S Page, L Richmond, MJ Earley, S Sporton, M Finlay, M Jones, JP Joseph, Y Bashir, TR Betts, A French, G Thomas, A Staniforth, P Kistler, K Rajappan, A Chow, RJ Schilling (Barts and the London NHS Trust & Queen Mary University of London, UK; The Heart Hospital, London UK; John Radcliffe Hospital, Oxford UK; Bristol Heart Institute, UK; Nottingham University Hospitals NHS Trust, UK; The Baker Heart Research Institute, Melbourne AU)

12. Ablation for Atrial Fibrillation - The Impact of Repeat Procedures - 10 Years of Single Centre Experience
PD Brown, J Tuan, AJ Sandilands, PJ Stafford, GA Ng (University of Leicester, UK; University Hospitals of Leicester, UK)

Cardiovascular Implantable Electronic Devices

14. An Atrial Lead does not Lower the Inappropriate ICD Therapy Rate in Patients with AF
WB Nicolson, AE Nicolson, S Chalil, AJ Sandilands, DT Chin, PJ Stafford, WI Loke, RK Pathmanathan, JD Skehan, GA Ng (Leicester Vardiovascular Biomedical Research Unit, UK; University of Cardiff, UK; University Hospitals of Leicester NHS Trust, UK)

15. Single Centre Experience of MR-Conditional Pacemaker Leads: No Difference in Complication Rates and Procedure Times Compared with Use of Standard Leads
S Litlle, A Tank, S Allen, A Zaidi (Manchester Royal Infirmary, UK)

16. Cardiac Implantable Electronic Device Infection may be Successfully Managed with a Reburial Strategy in Selected Patients
HE Thomas, DJ Twomey, M Das, EJ Shepherd, CJ Plummer (Freeman Hospital, Newcastle UK)

17. Survey of Antibiotic Prophylaxis for Implantable Cardiac Electronic Device (ICED) Insertion
EM Lowe, MH Tayabjee, J Pratty, JAT Sandoe (Leeds General Infirmary, UK)

18. Percutaneous Lead Extraction in Octogenarians
SE Williams, A Arujuna, J Whitaker, AK Shetty, J Bostock, N Patel, M Cooklin, J Gill, M O'Neill, C Blauth, C Bucknall, S Hamid, CA Rinaldi (St Thomas' Hospital, London UK)

Oral Abstracts 2

Clinical Arrhythmia Practice

19. The Impact of Specialist Nurse Arrhythmia Clinics: Streamlining & Enhancing Patient Services
S Hackett, J Campbell, A Hall, A Iglesias, SA James, J Mudd, T Rice, L Robbins, S Taggart, C Wilson, NJ Linker (The James Cook University Hospital,  Middlesbrough UK)

20. Cost Efficacy Analysis of Current Family Screening Protocol following a Sudden Arrhythmic Death (SADS)
LM Nunn, A Weissler, J Bhar-Amato, S Ahsan, A Opel, MD Lowe, WJ McKenna, PM Elliott, PD Lambiase (The Heart Hospital, University College of London, UK)

21. Cardiac Resynchronisation Therapy using the Radpad Radiation Shield at Implant Significantly Reduces Radiation Dose to the Implanting Physician
MA Jones, R Khiani, M Cocker, E Ilsley, P Foley, N Qureshi, T Betts, K Rajappan, Y Bashir (John Radcliffe Hospital, Oxford UK)

22. Temporal Trends in the Hospital Burden of Atrial Fibrillation and Stroke on Secondary Care Costs in England between 2006 and 2009
A Bakhai, C Righetti, Y Punekar, A Majeed (AMORE Health Ltd, London UK; Sanofi-Aventis, Guildford UK; Imperial College, London UK)

23. Clinical Coding for Electrophysiology and Device Procedures: Why and how to make it better
AJ Hogarth, MH Tayebjee, LN Graham, CB Pepper (Leeds General Infirmary, UK)

24. Pan-Hypopituitarism presenting as Syncopal Long QT
JD Lane, NG Keenan, P Bouloux, D Rogers (The Heart Hospital, London UK; Watford Hospital, UK; Royal Free Hospital, London UK)

Basic Science and CRT

25. Enhancement of Gap Junctional Coupling during Acute Myocardial Infarction reduces Late Post-Infarction Susceptibility to Ventricular Arrhythmias
FS Ng, JM Kalindjian, RA Chowdhury, PM Patel, CH Roney, E Dupont, AR Lyon, NS Peters (Imperial College London, UK)

26. Electrical Restitution in Single Cells - Effects of Acetylcholine and Nitric Oxide Donors
RR Patel, KE Brack, JS Mitcheson, GA Ng (University of Leicester, UK)

27. Haemodynamic Consequences of Targeted Single and Dual Site Right Ventricular Pacing in Adults with Congenital Heart Disease undergoing Surgical Pulmonary Valve Replacement
CM Plymen, AP Bolger, M Finlay, N Picaut, S Cullen, JE Deanfield, F Walker, TY Hsia, V Tsang, PD Lambiase (The Heart Hospital, University College of London, UK; Glenfield Hospital, Leicester UK; Great Ormond Street Hospital, London UK)

28. AV Delay Optimisation of Cardiac Resynchronisation Therapy using Invasive Haemodynamic Measurements is Insufficiently Reproducible to be Clinically Useful; Unless Multiple Replicate Measurements Relative to a Reference AV Delay are taken
ZI Whinnett, A Denis, K Willson, P Pascale, P Ritter, DP Francis, M Haissaguerre, P Bordachar (Hopital Haut-Leveque, Bordeaux-Pessac FR; Imperial College London, UK)

29. Is Real-Time CMR Dyssynchrony a Useful Tool in Guiding Lead Placement during CRT?
AK Shetty, SG Duckett, Y Ma, MR Ginks, J Bostock, M Sohal, G Carr-White, K Rhode, R Razavi, CA Rinaldi (Kings College London, UK; Guy's and St Thomas' Hospital, London UK)

30. Adverse Response to Cardiac Resynchronisation Therapy in Patients with Septal Scar on Cardiac MRI Preventing a Septal Right Ventricular Lead Position
SG Duckett, MR Ginks, A Shetty, S Kirubakaran, J Bostock, S Kapetanakis, J Gill, GS Carr-White, R Razavi, CA Rinaldi (Kings College London, UK; Guy's and St Thomas' Hospital, London UK)

Moderated Posters 1

31. High Rate of Appropriate Therapy Justifies ICD Use in Elderly Patients
WB Nicolson, AE Nicolson, AJ Sandilands, DT Chin, PJ Stafford, WI Loke, RK Pathmanathan, JD Skehan, GA Ng (Leicester Cardiovascular Biomedical Research Unit, Leicester UK; University of Cardiff, UK; University Hospitals of Leicester NHS Trust, UK)

32. First Experience of a New Remote Catheter System for Ablation of Atrial Fibrillation using 3D Mapping Systems
PD Brown, S Yusuf, S Chalil, AJ Sandilands, PJ Stafford, GA Ng (University of Leicester, UK; University Hospitals of Leicester, UK)

33. Mitral Isthmus Ablation is Feasible, Effacious and Safe using Robotic Remote Navigation System
K Wong, M Jones, N Qureshi, Y Bashir, TR Betts, K Rajappan (John Radcliffe Hospital, Oxford UK)

34. Persistent Atrial Fibrillation Ablation guided by Selective Continuous Activity Mapping: Towards more Effective Targeting of Fractionated Sites
PB Lim, M Finlay, J McCready, X Jie, L Xu, S Ahsan, AB Gopalamurugan, L Nunn, AW Chow, MD Lowe, OR Segal, E Rowland, P Lambiase (The Heart Hospital, University College London, UK)

35. Complex Cardiac Device Implantation in a Large District General Hospital - Can it be done well?
LTM Yung, S Wilson, RT Johnston, AKB Slade (Royal Cornwall Hospital, Truro UK)

36. Cost Analysis of Early Cardiac Device Infections
B Saberwal, SY Ahsan, PD Lambiase, OR Segal, M Lowe, C Koo, AB Gopalamurugan, E Rowland, L Nunn, AWC Chow (The Heart Hospital, London UK)

37. Patient Satisfaction with Nurse-Led Follow Up Service for Atrial Fibrillation facilitated by Implantable Reveal XT Devices
M Castro, PB Lim, M Dhaliwal, S Ahsan, AB Gopalamurugan, L Nunn, M Finlay, R Simon, MD Lowe, P Lambiase, AW Chow, E Rowland, O Segal (The Heart Hospital, University College London, UK)

38. Should Persistent Atrial Fibrillation always be Managed in Secondary Care? A Comparative Study of Current Practice
AN Jordan, AC Slater, CA Blakemore (Poole General Hospital, UK; Whitecliff Surgery, Blandford Forum UK)

Moderated Posters 2

39. Long QT3 Mice have Disrupted Sympathovagal Balance and in Vivo Ventricular Stimulation does not determine Risk of Sudden Cardiac Death, Suggesting that a Second Perturbation to Increase Vagal Tone may be Critical
A Opel, CLH Huang, A Grace, A Tinker (University College London, UK; University of Cambridge, UK; Papworth Hospital, Cambridge UK)

40. RGS 4 KO MIce are Predisposed to Atrial Fibrillation (AF) and show Disrupted Sympathovagal Balance in Vivo, Making RGS 4 a Potential Novel Therapeutic Target for AF
A Opel, A Tinker (University College London, UK)

41. Arrhythmic Burden in Families with Hypertrophic Cardiomyopathy related to Myosin Binding Protein C Mutations
SP Page, S Kounas, PS Andersen, P Syrris, MI Christiansen, PM Elliott, WJ McKenna (The Heart Hospital, University College of London, UK; Statens Serum Institut, Copenhagen DK)

42. LV Pacing and the Difference in Acute Haemodynamic Response within Individual Branches of the Coronary Sinus
AK Shetty, SG Duckett, Y Ma, S Kapetanakis, M Ginks, J Bostock, G Carr-White, K Rhode, R Razavi, CA Rinaldi (Guy's and St Thomas' NHS Foundation Trust, London UK; Kings College London, UK)

43. Benefits of Endocardial and Multi-Site Pacing are Dependent on the LV Electrical Activation Pattern and Presence of Ischaemic Heart Disease: Insights from Electro-Anatomical Mapping
MR Ginks, PD Lambiase, SG Duckett, A Shetty, J Bostock, C Bucknall, R Razavi, GS Carr-White, CA Rinaldi (St Thomas' Hospital, London UK; The Heart Hospital, London UK; Kings College London, UK)

44. The Electrophysiological Characteristics of Ventricular Arrhythmias and their relation to Cardiac Phenotype in Hypertrophic Cardiomyopathy
C O'Mahony, PD Lambiase, S Rhaman, M Cardona, G Quarta, M Calcagnino, K Tsovolas, S Al-Shaikh, WJ McKenna, PM Elliott (The Heart Hospital, London UK)

45. Dynamic Conduction and Repolarisation Changes can help Distinguish between Arrhythmic Right Ventricular Cardiomyopathy and Benign Right Ventricular Outflow Tract Tachycardia
MC Finlay, A Ahmed, J Barr-Amato, C Butcher, X Jie, O Segal, M Lowe, R Simon, A Chow, W McKenna, A Pantazis, PD Lambiase (The Heart Hospital, University College London, UK)

46. Characteristics of Eligible Patients who are not referred for Cardiac Resynchronisation Therapy
V Nayar, N Hiari, MRD Belham, DP Dutka, PJ Pugh (Addenbrooke's Hospital, Cambridge UK, University of Cambridge, UK)

Poster Session 1

47. Disparate Coronary Sinus Activation Pattern during Atrial Tachycardia after Persistent Atrial Fibrillation Ablation: Prevalence, Pitfalls and Impact on Mapping
P Pascale, ZI Whinnett, L Roten, A Shah, S Miyazaki, D Scherr, S Wilton, M Pedersen, N Derval, S Knecht, F Sacher, M Hocini, M Haissaguerre, P Jais (Hopital Haut-Leveque, Bordeaux-Pessac FR)

48. The Interaction between Warfarin and Heparin in Patients undergoing Catheter Ablation for Atrial Fibrillation with a Therapeutic International Normalized Ratio
SP Page, MS Siddiqui, RJ Hunter, L Richmond, MJ Earley, SC Sporton, M Dhinoja, RJ Schilling (St Bartholomew's Hospital, London UK)

49. The Right Lower Ganglionated Plexus is the "Gateway" to the AV Node
LC Malcolme-Lawes, PB Lim, I Wright, A Mason, TV Salukhe, P Kojodjojo, DW Davies, NS Peters, P Kanagaratnam (Imperial College London, UK; Imperial College Healthcare, London UK)

50. Pulmonary Vein Ectopy Generation is Abolished by Ablation of the Ganglionated Plexi
L Malcolme-Lawes, PB Lim, I Wright, S Jamil-Copley, TV Salukhe, P Kojodjojo, DW Davies, NS Peters, P Kanagaratnam (Imperial College London, UK; Imperial College Healthcare, London UK)

51. Ripple Mapping - A Rapid and Accurate Method for Displaying 3D Electrical Activation
S Jamil-Copley, P Kojodjojo, M Koa-Wing, L Malcolme-Lawes, T Salukhe, PB Lim, N Linton, DW Davies, N Peters, D Francis, P Kanagaratnam (St Mary's Hospital, Imperial College Healthcare NHS Trust, London UK)

52. Evidence for Cyclic Temporal Variability from High Frequency Re-Entrant Circuits in Persistent Atrial Fibrillation
JL Salinet Jr, PD Brown, GR Lohiya, S Bidder, PJ Stafford, FS Schlindwein, GA Ng (University of Leicester, UK; Glenfield Hospital, Leicester UK)

53. A Randomised Prospective Cardiac MR Comparison of Lesions created by Robotic Assisted versus Standard Ablation in Patients with Paroxysmal Atrial Fibrillation
A Arujuna, R Karim, M Wright, A Rinaldi, M Cooklin, K Rhode, R Razavi, M O'Neill, J Gill (St Thomas' Hospital, London UK)

54. Safety & Efficacy of Higher Initial Energy for Electrical Cardioversion of Atrial Fibrillation under Conscious Sedation with Midazolam
S Koganti, V Carnall, O Lawton, A Costello, M Been, F Osman (University Hospital of Coventry, UK)

55. Short-term Peri Infarction Gap Junction Modulation with Rotigaptide Reduces the Structural Heterogeneity of the Healed Infarct Border Zone
JM Kalindjian, FS Ng, PM Patel, RA Chowdhury, E Dupont, AR Lyon, NS Peters (Imperial College London, UK)

56. Early Repolarisation is Accentuated by Hypothermia in Ischaemic but not Idiopathic VF Cardiac Arrest
SE Williams, N Linton, M Wright, CN Floyd, N Barrett, M Shankar-Hari, M O'Neill (St Thomas' Hospital, London UK)

Poster Session 2

57. Elimination of Phrenic Nerve Stimulation occurring during CRT: Follow-up in Patients Implanted with a Novel Quadripolar Pacing Lead
PA Mehta, AK Shetty, M Squirrel, J Bostock, CA Rinaldi (Guys and St Thomas' NHS Foundation Trust, London UK)

58. Endocardial Left Ventricular Lead Implantation using a Gooseneck Snare and Transseptal Puncture: An Alternative Approach to Coronary Sinus Cannulation
GA Wright, I Lines, DR Tomlinson, GA Haywood (Derriford Hospital, Plymouth UK)

59. 'Quin-Site' CRT Pacing from the LV Endocardium, RV Endocardium, LV Epicardium and Two Vectors of a Quadripolar Lead Simultaneously
AK Shetty, S Neiderer, J Bostock, M Ginks, SG Duckett, Y Ma, Z Chen, M Sohal, P Mehta, S Kapetenakis, G Carr-White, CA Rinaldi (Guys and St Thomas' NHS Foundation Trust, London UK; Kings College London, UK)

60. Fully Automatable, Non-Invasive Plethysmographic Optimization of Cardiac Resynchronization Therapy: A Miniaturizable and Implantable Technology
A Kyriacou, P Pabari, D Lefroy, DW Davies, N Peters, P Kanagaratnam, J Mayet, A Hughes, DP Francis, ZI Whinnett

61. Inter-Atrial Conduction Time and Atrial High Rate Episodes in Patients with Permanent Pacemaker
CW Khoo, S Krishnamoorthy, G Dwivedi, GYH Lip, HS Lim (City Hospital, Birmingham UK)

62. Right Ventricular Pacing and Cardiac Remodelling
CW Khoo, S Krishnamoorthy, G Dwivedi, GYH Lip, HS Lim (City Hospital, Birmingham UK)

63. Important Differences in BPEG/CCAD Pacemaker Coding between Physiologists and Cardiologists
G Nallur Shiva, V Brooks, MJ Johns, RA Bleasdale (Royal Glamorgan Hospital, Llantrisant UK)

64. Non-Ischaemic Dilated Cardiomyopathies or Atrial Fibrillation - Device Therapy should not be withheld in the absence of NICE Guidance
LTM Yung, S Wilson, AKB Slade, RT Johnston (Royal Cornwall Hospital, Truro UK)

65. Assessment of Intracardiac Hemodynamics in Children with Ventricular Premature Beats from RVOT and LVOT
AA Chernyshev, IA Kovalev, KV Zavadovsky, SV Popov (Institute of Cardiology, Tomsk RU)

66. Prevalence of Asymptomatic Atrial Fibrillation and Evaluation of Thromboembolic Risk in Patients with DDD/AAI PM: Observational Follow-up Study
P Garg, I Khan, H Douglas (Aintree Cardiac Centre, Liverpool UK)